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KMID : 0615720100270020059
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Jouranl of Korean Acupuncture and Moxibustion society
2010 Volume.27 No. 2 p.59 ~ p.69
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The Effects of Lumbricus Pharmacopuncture on the Lipid Lowering, Anti-oxidative Activity and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet
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Gwon Kang
Park Hee-Soo
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Abstract
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Objectives : This study was designed to investigate effects of Lumbricus pharmacopuncture (LP) on the lipid lowering, anti-oxidative activity and concentration of proinflammatory cytokines in rat fed high fat diet.
Methods : Sprague-Dawley male rats were fed high fat diet for 8 weeks and experimental groups were divided into 4 groups as follows : Control, Lumbricus Jungwan (CV12) pharmacopuncture (T Ⅰ), Lumbricus Joksamni (ST36) pharmacopuncture (T Ⅱ), Lumbricus Jungwan (CV12) and Joksamni (ST36) pharmaco- puncture (T Ⅲ).
Results : The levels of plasma FFA, TG, total cholesterol, LDL-C, TBARS, IL-1β, IL-6, TNF-α and liver total cholesterol, TG, TBARS, SOD, catalase, IL-6 in more than one LP group were significantly lower than those of Control groups. The level of IL-10 in one of LP groups was significantly higher than that of Control group.
Conclusions : As the results were shown, LP treatment have considerable effects on lipid lowering, anti-oxidative activity and concentration of proinflammatory cytokines in rat fed high fat diet.
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KEYWORD
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obesity, Lumbricus pharmacopuncture, cholesterol, TG, TBARS, SOD, adipokine
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